Obesity and Dyslipidemia as Risk Factors of Vascular Cognitive Impairment in Adult Hypertensive Nigerian

Hypertension impairs the cerebral vasculature resulting in vascular cognitive impairment [VCI]. The role of obesity and plasma lipids shown as risk factors development VCI adults with hypertension is unclear investigated this study.
 Normoglycemic individuals [n=216] aged 40-75 years were enrolled into study between January December 2019. They included Newly Diagnosed Hypertensives [NDHCI, n-69] without Cognitive Impairment [NDH, n-81], age-matched 66 apparently healthy [Controls]. Anthropometric measures [height, weight, waist circumference [WC], Hip [HC], hip rratio [WHR] body mass index [BMI] socio-demographic indices, lifestyle blood pressure obtained using standard methods. Plasma [Total cholesterol [TC], high density lipoprotein [HDL-C], Triglyceride [TG] determined spectrophotometrically, while low [LDL-C] was calculated Friedewald formula. Neuropsychological assessment based on score [CS] done community screening instrument for dementia [CSID]. Data analyzed statistical package social sciences [SPSS] software 17.0 version. Analysis variance [ANOVA] Post Hoc test used comparison variables Chi square to find associations variables. These considered significant at p<0.05.
 indicators [WHR, WC BMI] dyslipidemia [TC, LDL-C triglyceride] levels significantly higher NDHCI [WHR=76.97±0.89, WC=37.67±0.61, BMI=28.09±0.49; TC=206.89±3.91, LDL-C=135.76±3.81, triglyceride=135.38±1.63] NDH [WHR=70.71 ± 0.10] WC=34.74 0.04,BMI= 28.30 0.49 TC=192.83 4.28,LDLC= 120.35 3.22,Triglyceride=127.00 2.69] relative control [WHR=51.99 0.83, WC=32.94 0.22, BMI=23.89 0.30 TC=104.70 7.19,LDLC= 94.80 1.90,Triglyceride=72.77 3.70], p<0.01. Significantly scores found NDHCI[3.48±0.38] compared [18.77±0.50] [28.76±0.16], p<0.001. WHR had inverse relationships [β= -14.627, p= 0.306] -0.031, p=0.005] respectively. Moreover, [β=12.315, p=0.049], HC [β=12.241, p=0.036] [β=496.374, p=0.043] group, a positive relationship DBP.
 Obesity atherogenic dyslipidaemia may be associated progression Nigerian hypertensive adults.